| A modified simplex method for multifactor optimization of selectivity in gas chromatography |
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| 作者姓名： | WANG Qin-Sun ZHU Chang-Shou YAN Bing-WenNational Laboratory of Elemento-Organic Chemistry Nankai University Tianjin China |
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| 作者单位： | WANG，Qin-Sun ZHU，Chang-Shou YAN，Bing-WenNational Laboratory of Elemento-Organic Chemistry，Nankai University，Tianjin 300071，China |
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| 基金项目： | supported by the National Natural Science Foundation of China. |
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| 摘 要： | A computer-assisted advanced simplex method is presented for the simultaneous optimization of multifactor ( stationary phase loading, carrier gas flow rate and column temperature ) for separation of ten compounds in gas chromatography. A three factors factorial design was used. The method was based on a special polynomial established from fifteen preliminary runs, using resolution as the selection criterion, with connection to a general simplex method. Excellent agreement is found between the predicted data and the experimental results, and most of experiments required in the general simplex method can be omitted.
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A modified simplex method for multifactor optimization of selectivity in gas chromatography |
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| WANG,Qin-Sun ZHU,Chang-Shou YAN,Bing-WenNational Laboratory of Elemento-Organic Chemistry,Nankai University,Tianjin ,China.A modified simplex method for multifactor optimization of selectivity in gas chromatography[J].Chinese Journal of Chemistry,1995(2). |
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| Authors: | WANG Qin-Sun ZHU Chang-Shou YAN Bing-WenNational Laboratory of Elemento-Organic Chemistry Nankai University Tianjin China |
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| Institution: | WANG,Qin-Sun ZHU,Chang-Shou YAN,Bing-WenNational Laboratory of Elemento-Organic Chemistry,Nankai University,Tianjin 300071,China |
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| Abstract: | A computer-assisted advanced simplex method is presented for the simultaneous optimization of multifactor ( stationary phase loading, carrier gas flow rate and column temperature ) for separation of ten compounds in gas chromatography. A three factors factorial design was used. The method was based on a special polynomial established from fifteen preliminary runs, using resolution as the selection criterion, with connection to a general simplex method. Excellent agreement is found between the predicted data and the experimental results, and most of experiments required in the general simplex method can be omitted. |
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| Keywords: | Gas chromatography stationary phase carrier gas flow rate column temperature multifactor optimization |
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