STUDIES ON THE STRUCTURE OF PORPHYRINS CONTAINED IN PHOTOFRIN® II |
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| Authors: | Thomas J. Dougherty |
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| Affiliation: | Division of Radiation Biology, Department of Radiation Medicine, Roswell Park Memorial Institute, 666 Elm Street, Buffalo, NY 14263, USA |
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| Abstract: | Abstract Using three methods to attempt to identify the presence of ester-linked porphyrins in Photofrin® II, lithium aluminum hydride reduction, basic hydrolysis and proton NMR. it can be concluded that 40-50% of such linkages are present. The majority of the remaining material is cleaved by acid hydrolysis, which is consistent with the ether structure proposed earlier. earlier. |
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