Alkaloids from stems of Esenbeckia leiocarpa Engl. (Rutaceae) as potential treatment for Alzheimer disease |
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Authors: | Cardoso-Lopes Elaine Monteiro Maier James Andreas da Silva Marcelo Rogério Regasini Luis Octávio Simote Simone Yasue Lopes Norberto Peporine Pirani José Rubens Bolzani Vanderlan da Silva Young Maria Cláudia Marx |
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Affiliation: | Section of Plant Physiology and Biochemistry, Institute of Botany, Box 3005, 01061-970 S?o Paulo, SP, Brazil. |
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Abstract: | Esenbeckia leiocarpa Engl. (Rutaceae), popularly known as guarant?, goiabeira, is a native tree from Brazil. Bioactivity-guided fractionation of the ethanol stems extract afforded the isolation of six alkaloids: leiokinine A, leptomerine, kokusaginine, skimmianine, maculine and flindersiamine. All isolated compounds were tested for acetyl cholinesterase inhibition, in vitro and displayed anticholinesterasic activity. The alkaloid leptomerine showed the highest activity (IC?? = 2.5 mM), similar to that of the reference compound galanthamine (IC?? = 1.7 mM). The results showed for the first time the presence of alkaloids leptomerine and skimmianine in E. leiocarpa (Engl.) with potent anticholinesterasic activity. |
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