A Double Mannich-type Reaction in the 1,4,5,6-Tetrahydropyridine-2-thiolate Series: A Convenient Approach to Functionalized 3,7-Diazabicyclo[3.3.1]nonane Derivatives |
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| Authors: | Victor V. Dotsenko Sergey G. Krivokolysko Victor P. Litvinov |
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| Affiliation: | (1) “ChemEx” Laboratory, Vladimir Dal’ East Ukrainian National University, Lugansk, Ukraine;(2) Russian Academy of Sciences, Zelinsky Institute of Organic Chemistry, Moscow, Russian Federation |
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| Abstract: | Summary. The reaction of N-methylmorpholinium 5-alkoxy-carbonyl-4-aryl-3-cyano-2-oxo-1,4,5,6-tetrahydropyridine-2-thiolates with primary amines and formaldehyde under mild conditions afforded 7-substituted alkyl 9-aryl-5-cyano-2-oxo-4-thioxo-3,7-diazabicyclo[3.3.1]nonane-1-carboxylates in fair to good yields (52–74%). Third author was Deceased on February 26, 2007 |
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| Keywords: | . Heterocycles Cyclizations Mannich reaction 3,7-Diazabicyclo[3.3.1]nonanes Pyridine-2-thiolates. |
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