Highly sensitive electrochemical detection of mercury (II) via single ion-induced three-way junction of DNA |
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| Institution: | 1. College of Chemistry and Chemical Engineering, Qinghai University for Nationalities, Xining, Qinghai 810007, China;2. College of Physics and Electronic Information Engineering, Qinghai University for Nationalities, Xining, Qinghai 810007, China;3. School of Chemistry and Environmental Science, Lanzhou City University, Lanzhou, Gansu 730070, China |
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| Abstract: | A “signal-on” electrochemical sensing strategy was designed for highly sensitive and selective detection of mercury (II) via its induction to three-way junction of DNA (DNA-TWJ). The TWJ consisted of the capture probe that was self-assembled on a gold electrode surface through S Au bond, the signal probe that was labeled with ferrocene (Fc) and contained single T–T mismatch to capture probe, and an assistant probe for the formation of DNA-TWJ upon the presence of mercury (II). This process caused the Fc tag approaching the electrode for fast electron transfer and thus increased the oxidation current. The “signal-on” sensing method could detect Hg2 + ranging from 0.005 to 100 nM. The assay was simple and fast. It showed potential application in on-site and real-time Hg2 + detection. |
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