Mesoporous silica thin film mechanized with a DNAzyme-based molecular switch for electrochemical biosensing |
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| Affiliation: | 1. Department of Analytical Chemistry, Faculty of Chemistry, Complutense University of Madrid, 28040-Madrid, Spain;2. Department of Chemistry, Faculty of Sciences, University of Tunis El Manar, Rue Béchir Salem Belkheria, Tunis El-Manar 2092, Tunis, Tunisia;1. College of Environmental Science and Engineering, Donghua University, Shanghai 201620, PR China;2. Research Center for Analysis & Measurement, Donghua University, Shanghai 201620, PR China |
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| Abstract: | A novel electroanalytical strategy for copper and ascorbic acid detection was developed by using a nanostructured electrode surface mechanized with a DNAzyme-based molecular gate. This sensing interface was constructed by first electrodeposition of a mesoporous silica thin film on Au electrodes and further assembly of a Cu(II)-specific DNAzyme. The biosensing assay was based on the Cu(II) and ascorbic acid responsible activation of the DNAzyme, which acted as a molecular switch able to control the diffusion of the Fe(CN)63 −/4 − electrochemical probe through the nanochannels of the mesoporous film. |
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