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On the impact of discreteness and abstractions on modelling noise in gene regulatory networks
Affiliation:1. Dip. di Informatica, Università di Pisa, Italy;2. Dip. di Matematica e Geoscienze, Università di Trieste, Italy;3. Max Planck Institut of Colloids and Interfaces, Potsdam, Germany;4. Systems Biology Ireland, University College Dublin, Ireland;5. Dip. di Matematica e Informatica, Università di Udine, Udine, Italy;6. Centre for Integrative Biology (CIBIO), University of Trento, Italy;7. CNR-ISTI, Pisa, Italy;8. Modelling and Simulation Group, University of Saarland, Campus E 1 3, Saarbruecken, Germany;1. Department of Chemistry, Fisher College of Science and Mathematics, Towson University, 8000 York Road, Towson, MD 21252, USA;2. Department of Chemistry, University of Wisconsin – Stevens Point, 2001 Fourth Avenue, Stevens Point, WI 54481, USA​;1. Nano-Bio Spectroscopy Group and ETSF Scientific Development Centre, Departamento de Fisica de Materiales, Universidad del Pais Vasco UPV/EHU, Avenida de Tolosa 72, San Sebastian E-20018, Spain;2. Institute for Spectroscopy Russian Academy of Science, Fizicheskaya Str. 5, Troitsk 142190, Moscow, Russia;3. Kintech Lab Ltd., Kurchatov Sq. 1, Moscow 123182, Russia;4. National Research Centre “Kurchatov Institute”, Kurchatov Sq. 1, Moscow 123182, Russia;5. Moscow Institute of Physics and Technology, Institutskii pereulok 9, Dolgoprudny 141700, Moscow Region, Russia;6. Physics Department, Belarusian State University, pr. Nezavisimosti 4, Minsk 220030, Belarus;1. Department of Physics, Faculty of Science, University of Bamenda, Bambili P. O. Box 39, Cameroon;2. Department of Physics, Faculty of Science, University of Maroua, Maroua P. O. Box 814, Cameroon;3. Department of Physics, Higher Teacher’s Training College, University of Maroua, Maroua P. O. Box 46, Cameroon;4. Department of Physics, Faculty of Science, University of Ngaoundéré, Ngaoundéré P. O. Box 454, Cameroon;5. Laboratory of Fundamental Physics, Faculty of Science, University of Douala, Douala P. O. Box 24157, Cameroon;1. Department of Informatics, Systems and Communication (DISCo), University of Milano - Bicocca, Italy;2. Department of Computer Science, University of Pisa, Italy;3. ERABLE Team, INRIA, France;4. CWI, Amsterdam, the Netherlands
Abstract:
Keywords:Gene regulatory networks  Discrete modelling  Hybrid system  Quasi-steady state approximation  Stochastic noise
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