A facile route to the synthesis of pyrimido[2,1-b]quinazoline core from the primary allyl amines afforded from Baylis–Hillman adducts |
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Authors: | Somnath Nag Amita Mishra Sanjay Batra |
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Affiliation: | aMedicinal and Process Chemistry Division, Central Drug Research Institute, PO Box 173, Lucknow 226001, India |
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Abstract: | A highly simplified approach for the generation of substituted pyrimido[2,1-b]quinazoline core from the primary allyl amines afforded from the Baylis–Hillman adducts is described. Sequential reductive alkylation of the primary allyl amine with 2-nitrobenzaldehyde, reduction of the aromatic nitro group with In, CNBr-promoted intramolecular cyclization followed by NaOMe-mediated another intramolecular cyclization furnish the title compounds. |
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Keywords: | Baylis– Hillman Allyl amine BrCN Pyrimido[2,1-b]quinazoline In Intramolecular cyclization |
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