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Design and synthesis of DPP-4 inhibitor for the treatment of type 2 diabetes |
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| Authors: | Peng Cho Tang Zhi Gang Lin Yang Wang Fang Long Yang Qian Wang Jian Hong Fu Lei Zhang Ai Shen Gong Jing Jing Luo Jun Dai Gao Hong She Dan Dan Si Jun Feng |
| Institution: | Shanghai Hengrui Pharmaceuticals Co. Ltd., 279 Wenjing Road, Shanghai 200245, China |
| Abstract: | An efficient stereoselective synthesis of the rigid aza-bicyclo3.2.0]heptane scaffold has been developed to provide 2-cyano-pyrrolidine alpha-amino amide 1 as DPP-4 inhibitor. |
| Keywords: | DPP-4 inhibitor Aza-bicyclo[3 2 0]heptane scaffold 2-Cyanopyrrolidine alpha-amino amide derivative Synthesis Type 2 diabetes |
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