Identification of efficient and sequence specific bimolecular artificial ribonucleases by a combinatorial approach |
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| Authors: | Kalek Marcin Benediktson Peter Vester Birte Wengel Jesper |
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| Institution: | The Nucleic Acid Center, Department of Physics and Chemistry, University of Southern Denmark, DK-5230, Odense M, Denmark. |
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| Abstract: | Chemically modified nucleotide monomers were incorporated into adjacent terminal positions of two separate oligonucleotides complementary to an RNA target; all possible combinations of the catalytic units were tested, resulting in an artificial nuclease that showed high activity and catalytic turnover. |
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