Synthesis and antimicrobial evaluation of 6-azauracil non-nucleosides |
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Authors: | Nasser R El-Brollosy |
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Institution: | (1) Department of Chemistry, Faculty of Science, Tanta University, Tanta, Egypt |
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Abstract: | The present study describes synthesis and antimicrobial evaluation of a series of novel 6-azauracil non-nucleosides. Reaction
of silylated 6-azauracils with the appropriate chloroethers gave the corresponding non-nucleosides. 1-(Allyloxymethy)-6-azauracils
and non-nucleosides bearing indanyl, cyclohexenyl, and cyclohexyl moieties were obtained via silylation of 6-azauracils followed by treatment with the appropriate acetals. Selected compounds were tested for their in vitro antimicrobial activity against a panel of standard strains of Gram-positive and Gram-negative bacteria and the yeast-like pathogenic fungus Candida albicans. Four compounds showed marked inhibitory activity particularly against the tested Gram-positive bacteria.
Correspondence: Nasser R. El-Brollosy, Department of Pharmaceutical Chemistry, College of Pharmacy, King Saud University,
P.O. Box 2457, Riyadh 11451, Saudi Arabia. |
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Keywords: | 6-Azauracils 6-Azathymines 1 2 4-Triazine-3 5-diones Non-nucleosides Antimicrobial activity |
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