Analysis of Fatty Acid, and Lipoprotein, Metabolism by GC and HPLC: Effect of Low-Density Lipoprotein Apheresis |
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| Authors: | Vladimír Bláha Dagmar Solichová Milan Bláha Eduard Havel Melanie Pivokonska Zdeněk Zadák |
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| Institution: | (1) Department of Metabolic Care, Charles University, Medical School and Teaching Hospital, Sokolská 581, 50005 Hradec Králové, Czech Republic,;(2) Department of Haematology, Charles University, Medical School and Teaching Hospital, Sokolská 581, 50005 Hradec Králové, Czech Republic, |
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| Abstract: | Blood samples from 5 hyperlipidemic patients on chronic treatment with low-density lipoprotein (LDL) – apheresis were analysed
for lipids and fatty acids in serum, lipoprotein fractions and erythrocyte membrane by capillary gas chromatography (GC),
reversed-phase high-performance liquid chromatography (LC), spectrofluorometry and spectrophotometry. LDL-apheresis has been
associated with significant changes of fatty acids metabolism in relation to triglyceride-rich lipoproteins. Oleic acid may
exert its hypotriglyceridemic effect via VLDL, IDL, LDL and HDL fractions. Polyunsaturated fatty acids, associated with triglyceride
metabolism via IDL or VLDL, are linoleic, gamma-linolenic and docosahexaenoic fatty acids.
Received November 25, 1999. Revision September 5, 2000. |
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| Keywords: | : Fatty acids lipoprotein metabolism atherosclerosis hypercholesterolemia LDL-apheresis |
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