Expanding the chemical space in practice: diversity-oriented synthesis |
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Authors: | Peuchmaur Marine Wong Yung-Sing |
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Institution: | Département de Pharmacochimie Moléculaire, Université de Grenoble/CNRS UMR 5063, CNRS ICMG FR 2607 Batiment E, Batiment André Rassat, 470 rue de la Chimie, Grenoble Cedex 9, France. |
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Abstract: | Diversity-Oriented Synthesis (DOS) aims to broaden the frontier of accessible collections of complex and diverse small molecules. This review endeavours to dissect the DOS concept through three elements of diversity: building block, stereochemistry, and skeleton. Recent examples in the literature that emphasize the efficient combinations of these elements to generate diversity are reported. |
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