| 席夫碱及其金属配合物的合成及生物活性研究进展 |
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| 引用本文： | 王澈,侯鹏,李崧,邢永恒. 席夫碱及其金属配合物的合成及生物活性研究进展[J]. 化学通报, 2009, 72(4) |
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| 作者姓名： | 王澈 侯鹏 李崧 邢永恒 |
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| 作者单位： | 辽宁师范大学化学化工学院,大连,116029;大连理工大学,大连,116024;沈阳药科大学生命科学与生物制药学院,沈阳,110016 |
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| 摘 要： | 席夫碱及其金属配合物具有独特的抗菌、抗肿瘤和抗氧化等生物活性.为筛选高效低毒的药物,人们合成了大量不同类型的席夫碱及其金属配合物并对其生物活性进行了研究.本文综述了近年来席夫碱及其金属配合物的合成,以及在抗菌、抗氧化、抗肿瘤等方面生物活性的研究进展,并为进一步研究其在医药领域的应用提供了信息支持.
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| 关 键 词： | 席夫碱 金属配合物 合成 生物活性 |
Progress in Synthesis,Bioactivities of Schiff Base and its Metal Complexes |
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| Wang Che,Hou Peng,Li Song ,,Xing Yongheng. Progress in Synthesis,Bioactivities of Schiff Base and its Metal Complexes[J]. Chemistry, 2009, 72(4) |
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| Authors: | Wang Che Hou Peng Li Song Xing Yongheng |
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| Affiliation: | ~1 School of Chemistry and Chemical Engineering;Liaoning Normal University;Dalian 116029;~2 Dalian University of Technology;Dalian 116024;~3 School of Life Sciences and Biopharmacy;Shenyang Pharmaceutical University;Shenyang 110016 |
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| Abstract: | Schiff base and its metal complexes have significant antimicrobial,antitumor and antioxidant activities. In order to screen the high-efficiency drugs with low toxicity,a large number of Schiff bases and their metal complexes have been synthesized,and the bioactivity screening of these ligands and complexes were performed. In present paper,the progress of synthesis,antimicrobial,antitumor and antioxidant activities of some kinds of Schiff bases and their metal complexes are reviewed. |
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| Keywords: | Schiff base Metal complex Synthesis Bioactivities |
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