Solubility Measurements and Prediction of Coenzyme Q10 Solubility in Different Solvent Systems |
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| Authors: | Yin Zhao Yan-Hong Sun Zhi-Yong Li Chuang Xie Ying Bao Zhi-Jian Chen Jun-Bo Gong Qiu-Xiang Yin Wei Chen Cui Zhang |
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| Institution: | 1. Department of Chemical Engineering, School of Chemical Engineering and Technology, Tianjin University, Tianjin, 300072, China
2. Institute of New Catalytic Materials Science, Key Laboratory of Advanced Energy Materials Chemistry (MOE), College of Chemistry, Nankai University, Tianjin, 300071, China
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| Abstract: | The solubility of coenzyme Q10 in ethyl acetate, n-hexane, 1-butanol, 1-propanol, 2-propanol and ethanol in the temperature range 270.15–320.15 K, under atmospheric pressure, was measured by a gravimetric method and compared with the data predicted using the conductor like screening model for realistic solvation (COSMO-RS) method. The results show that the solubilities of coenzyme Q10 in the above solvents increase with temperature. The temperature dependences of predicted solubilities were consistent with the experimental data. The experimental data were correlated with the Apelblat equation. At the same temperature, the order of increasing solubility is ethyl acetate > n-hexane > 1-butanol > 1-propanol > 2-propanol > ethanol. |
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