Cardiac glycosides ofAcokanthera venenata

Six cardenolides have been isolated from the leaves ofAcokanthera venenata G. Don: AV-1, mp 252–255°C, []_D²⁰+39.4° (MeOH); AV-2, mp 199–208°C, []_D²⁰-59.3° (MeOH); AV-3, mp 269–275°C/300–304°C, []_D²¹ –69.8° (MeOH); AV-4, mp 279–289°C; AV-5, mp 222–225°, []_D²⁰-64.3° (MeOH); and AV-6, mp 193–196°C []_D²⁰–23.8° (MeOH — CHCl₃). AV-5 has been identified as acovenoside A. AV-3 is a new cardiac glycoside: it is 1-acetoxy-3-(4-O--D-glucosyl-3-O-methyl--L-talomethylosyloxy)-14-hydroxy-5, 14-card-20(22)-enolide (glucoacovenoside B).Khar'kov State Pharmaceutical Institute. All-Union Scientific Research Institute of Drug, Chemistry and Technology, Khar'kov. Translated from Khimiya Prirodnykh Soedinenii, No. 3, pp. 372–376, May–June, 1987.