The de novo methylation activity of Dnmt3a is distinctly different than that of Dnmt1 |
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Authors: | Email author" target="_blank">Chih-Lin?HsiehEmail author |
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Institution: | (1) Department of Urology and Department of Biochemistry and Molecular Biology, Norris Cancer Center, University of Southern California, 1441 Eastlake Ave.,Rm 5420, Los Angeles, CA 90033, USA |
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Abstract: | Background Though Dnmt1 is considered the primary maintenance methyltransferase and Dnmt3a and Dnmt3b are considered de novo methyltransferases
in mammals, these three enzymes may work together in maintaining as well as establishing DNA methylation patterns. It has
been proposed that Dnmt1 may carry out de novo methylation at sites in the genome with transient single-stranded regions,
such as replication origins, and then spread methylation from these nucleation sites in vivo, even though such activity has
not been reported. |
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Keywords: | |
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