Sequence specific interstrand photocrosslinking for effective SNP typing |
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| Authors: | Ami Takehiro Ito Katsuya Yoshimura Yoshinaga Fujimoto Kenzo |
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| Affiliation: | School of Materials Science, Japan Advanced Institute of Science and Technology, Ishikawa 923-1292, Japan. |
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| Abstract: | We describe a simple and inexpensive SNP typing method by using sequence specific interstrand photocrosslinking via p-carbamoylvinyl phenol nucleosides. Interstrand photocrosslinking showed a high degree of single nucleotide specificity as high as 10(3)-fold and more, and can be used in the diagnostic detection of DNA sequences. |
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