Generation of molecular diversity using a complexity-generating MCR-platform towards triazinane diones |
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| Authors: | Groenendaal Bas Ruijter Eelco de Kanter Frans J J Lutz Martin Spek Anthony L Orru Romano V A |
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| Affiliation: | Department of Chemistry and Pharmaceutical Sciences, Vrije Universiteit Amsterdam, De Boelelaan 1083, 1081, HV, Amsterdam, The Netherlands. |
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| Abstract: | Triazinane diones, readily generated by a recently reported multicomponent reaction, can be easily alkylated with various alkyl halides, allowing a wide variety of complexity-generating secondary reactions. Because of the high variability of the initial multicomponent reactions and the multiple possibilities for participation of substituents in the secondary reactions, a highly diverse set of complex products was obtained in short and efficient reaction sequences. |
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