|
|||||
|
|
Enantioselective epoxidation by the chiral auxiliary approach: Asymmetric total synthesis of (+)-Ambrisentan |
|
| Authors: | Madasu Madhu Sai Reddy Doda Prem Kumar Begari Krishna Rao Dasari Gangadhar Thalari Sudhakar Kadari Jhillu Singh Yadav |
| Affiliation: | 1. Department of Organic Synthesis and Process Chemistry, CSIR – Indian Institute of Chemical Technology, Hyderabad, India;2. Department of Chemistry, Osmania University, Hyderabad, India |
| Abstract: | Enantioselective and a highly concise total synthesis of Ambrisentan are described. The chiral auxiliary controlled enantioselective epoxidation (Azerad protocol), photochemical regioselective epoxide opening, and base mediated ester hydrolysis reactions are the key reactions. |
| Keywords: | Ambrisentan auxiliary controlled epoxidation Azerad protocol C-C bond formation total synthesis |