A combined multicomponent-acid catalyzed cyclization reaction as an efficient route to novel tricyclic pyrrolo[2,1-a]isoquinoline derivatives |
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| Authors: | Mehdi Ghandi Meysam Khodadadi Alireza Abbasi |
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| Affiliation: | School of Chemistry, College of Science, University of Tehran, Tehran, Iran |
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| Abstract: | A simple, new two-step procedure for the synthesis of novel tricyclic pyrrolo[2,1-a]isoquinoline derivatives is described. The initially prepared polysubstituted pyrroles obtained via the four-component condensation of arylglyoxals, cyclic 1,3-dicarbonyls, aminoacetaldehyde dimethyl acetal, and β-keto esters subsequently underwent intramolecular acid-catalyzed cyclization to the desired products in moderate to good yields. |
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