Catalyst free synthesis of 2-Aryl-2H-benzo[b][1,4]oxazines and 3-Aryl-2H-benzo[b][1,4]thiazin-2-ones: An ultrasonication-assisted strategy |
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| Authors: | Bisma Teli Malik Abdul Waseem Showkat Rashid Bilal Ahmad Ganaie Bilal A Bhat |
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| Institution: | 1. Natural Products and Medicinal Chemistry, CSIR-Indian Institute of Integrative Medicine, Jammu & Kashmir, India
Academy of Scientific & Innovative Research (AcSIR), Ghaziabad, India;2. Natural Products and Medicinal Chemistry, CSIR-Indian Institute of Integrative Medicine, Jammu & Kashmir, India |
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| Abstract: | An ultrasonication-assisted synthesis of 2-Aryl-2H-benzob]1,4]oxazines and 3-aryl-2H-benzob]1,4]thiazin-2-ones has been established by reacting phenacyl bromides with 2-aminophenol and 2-aminothiophenol, respectively. This approach fosters flexibility in generating a diverse range of 1,4-benzoxazines and 1,4-benzothiazinones under catalyst-free reaction conditions. Further scope toward the synthesis of rarely occurring bis-benzoxazine adduct has also been explored, which enabled us to propose the reaction mechanism. |
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