Development of an efficient,one-pot,multicomponent protocol for synthesis of 8-hydroxy-4-phenyl-1,2-dihydroquinoline derivatives |
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| Authors: | Rukhsana Tabassum Muhammad Ashfaq Hiroyuki Oku |
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| Institution: | 1. Department of Chemistry, The Islamia University of Bahawalpur, Bahawalpur, Pakistan;2. Division of Molecular Science, Graduate School of Science & Engineering, Gunma University, Gunma, Japan |
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| Abstract: | A one-pot quick and efficient multicomponent reaction has been developed for the synthesis of a new series of functionalized 8-hydroxy-4-phenyl-1,2-dihydroquinoline derivatives using 30 mol% ammonium acetate in ethanol as solvent. This economical protocol run smoothly to give variety of quinoline derivatives in 55% to 98% yield from inexpensive reagents and catalyst in mild reaction conditions. Various spectroscopic techniques like FTIR, 1H NMR and 13C NMR, MALDI-TOF-MS, and EI-MS were used to study and confirm their structure. |
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