Design and synthesis of two epoxide derivatives from 3-ethynylaniline |
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| Authors: | Lauro Figueroa-Valverde Diaz Cedillo Francisco Lopez-Ramos Maria Rosas-Nexticapa Marcela Mateu-Armand Virginia Lopez-Gutierrez Tomas Alvarez-Ramirez Magdalena |
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| Institution: | 1. Laboratory of Pharmacochemistry, Faculty of Biological-Chemical Sciences, University Autonomous of Campeche, Campeche, Mexico;2. Escuela de Ciencias Biologicas, Instituto Politecnico Nacional, Ciudad de Mexico, Mexico;3. Facultad de Nutrición, Universidad Veracruzana, Xalapa, Veracruz, Mexico |
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| Abstract: | For several years ago, several epoxide derivatives have been prepared using different methods; however, some protocols use reagents which could be expensive and require specials conditions. The aim of this investigation was to prepare two new epoxide-derivatives from 3-ethynylaniline using some reactions such as oximation, acetylation, 2 + 2 addition, functionalized chloroamides, and epoxidation via Darzens reaction. The chemical characteristics of epoxide derivatives were determinate through a spectroscopic and spectrometric analysis. In conclusion, it is noteworthy that the reactions used in this study do not involve expensive reagents or special conditions for the synthesis of epoxide derivatives. |
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