Antimicrobial effects of vanillin-based pyridyl-benzylidene-5-fluoroindolins |
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Authors: | Deena Gladies Raymond Mohanraj Manikandan Alagumuthu Palaniraja Subramaniam Dhivya Bakthavachalam Sivakumar Arumugam Subha Chellam |
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Affiliation: | 1. Department of Chemistry, Nirmala College for Women, Coimbatore, India;2. Department of Biotechnology, School of Biosciences and Technology, Vellore Institute of Technology, Vellore, India;3. Sigma-Aldrich Chemicals Pvt. Ltd (subsidiary of Merck KGaA), Bangalore, India |
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Abstract: | In this study, the antimicrobial effect and DNA gyrase inhibitor potential of vanillin-based pyridyl–substituted fluoro-indolines were evaluated. These compounds are synthesized and established through green-chemistry approaches. The inhibition effect on both DNA gyrase A and B was evaluated in silico and in vitro. Agar well diffusion method–based antimicrobial activity against Gram-ve Pseudomonas aeruginosa (MTCC 424) and Escherichia coli (MTCC 443), Gram+ve Streptococcus pyogenes (MTCC 442) and Staphylococcus aureus (MTCC 96), and a clinical isolate of Candida albicans (Fungi) was evaluated. The cytotoxicity of the compounds was assessed over macrophages using the MTT assay. In the results, the target compounds exhibited a broad-spectrum antimicrobial activity against both bacterial types and fungal. |
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