Silica sulfuric acid mediated synthesis of naphtho[2,1-b]furan derivatives and development of one-pot multicomponent synthesis of substituted pyrazole derivatives

Silica sulfuric acid (SSA) mediated synthesis of naphtho[2,1-b]furan derivatives starting from β-nitrostyrene derivatives and β-naphthol derivatives under solvent-free conditions have been developed. The scope of SSA as a heterogeneous catalyst is extended to one-pot multicomponent reaction for the synthesis of functionalized pyrazole derivatives under solvent-free conditions from readily available β-nitrostyrene derivatives, acetyl acetone, and hydrazine hydrate. The synthetic methods have significant advantages such as solvent-free conditions, simple operation, shorter reaction times, ease and clean isolation procedures, and very good yields of products.