Synthesis,biological evaluation,and docking studies of various β-substituted porphyrin conjugates embedded with N-containing heterocycles |
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| Authors: | Ghada S Masaret |
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| Institution: | Department of Chemistry, Faculty of Applied Science, Umm Al-Qura University, Makkah Almukkarramah, Saudi Arabia |
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| Abstract: | A new methodology for the synthesis of some new β-porphyrin heterocyclic compounds containing nitrogen derivatives 10 , 12 , 13 , 15 , 17 , 19 , 21 , 22 , 25 , 27 , and 29 was screened for their cytotoxic activities. Both elemental and spectral analyses were used to confirm the structures of new compounds. Compounds 22 , 27 , and 21 exhibited very strong activity against the HepG2 cell line. Investigation of the binding between porphyrin 22 and the binding site of telomerase was performed by molecular docking. |
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