Silyl Modification of Biologically Active Compounds. 8. Trimethylsilyl Ethers of Hydroxyl-containing Thiazole Derivatives |
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| Authors: | A Zablotskaya I Segal S Germane I Shestakova I Domracheva A Nesterova A Geronikaki E Lukevics |
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| Institution: | (1) Latvian Institute of Organic Synthesis, Riga, LV-1006;(2) Department of Pharmaceutical Chemistry, Aristotelian University of Thessaloniki, 54006 Greece |
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| Abstract: | Trimethylsilyl ethers of various hydroxyl-containing thiazole derivatives have been synthesized. The psychotropic activity (in vivo) and the cytotoxicity (in vitro on tumor cell lines HT-1080 and MG-22A) of these ethers and of their unsilylated precursors have been studied. It was discovered that the obtained compounds possess a sedative action. A moderate cytotoxic effect was detected for piperidine-containing thiazoles, displayed most strongly in relation to MG-22A cells. |
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| Keywords: | piperidine silyl group thiazole psychotropic activity silylation cytotoxicity |
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