Fabrication and in vitro drug release study of microsphere drug delivery systems based on amphiphilic poly-alpha,beta-[N-(2-hydroxyethyl)-L-aspartamide]-g-poly(L-lactide) graft copolymers |
| |
Authors: | Zhou Yu-Xiang Li Song-Lin Fu Hui-Li Cheng Si-Xue Zhang Xian-Zheng Zhuo Ren-Xi |
| |
Institution: | Key Laboratory of Biomedical Polymers of Ministry of Education, Department of Chemistry, Wuhan University, Wuhan 430072, People's Republic of China. |
| |
Abstract: | Biodegradable amphiphilic graft copolymers with different compositions were synthesized by grafting poly(L-lactide) (PLLA) sequences onto a water-soluble poly-alpha,beta-N-(2-hydroxyethyl)-L-aspartamide] (PHEA) backbone. The critical micelle concentration (CMC) of the graft polymers was determined by fluorescence probe technique. Using the MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) assay, the graft polymers were proved to have low cytotoxicity. Based on the specific physicochemical property of the graft copolymers, submicron sized microsphere drug delivery systems were prepared by a very convenient "ultrasonic dispersion method", which did not involve toxic organic solvents. The drug-loaded microspheres had a regular spherical shape with a narrow size distribution. A hydrophobic drug, prednisone acetate, was encapsulated into polymeric microspheres and the in vitro drug release was studied. |
| |
Keywords: | Controlled drug release Amphiphilic copolymer Fabrication Microsphere Biodegradation |
本文献已被 ScienceDirect PubMed 等数据库收录! |
|