| Synthesis and Crystal Structure of Ethyl 2-（6-（1,3-Dioxo-4,5,6,7-tetrahydro-lH- isoindol-2（3H）-yl）-7-fluoro-3-oxo-2H- benzo[b][1,4]oxazin-4（3H）-yl） Butanoate |
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| 作者姓名： | WU Dao-Xin ;LUO Fei-Xian ;MO Hong-Bo ;WANG Xiao-Guang ;REN Ye-Guo ;SIMPSON Jim ;HUANG Ming-Zhi |
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| 作者单位： | [1]School of Chemistry and Biological Engineering, Changsha University of Science and Technology, Changsha, Hunan 410076, China; [2]Key Laboratory of Chemical Biology and Traditional Chinese Medicine Research (Ministry of Education of China), Hunan Normal University, Changsha 410081, China; [3]National Engineering Research Center for Agrochemicals, Hunan Research Institute of Chemical Industry, Changsha 410007, China; [4]Department of Chemistry, University of Otago, PO Box 56, Dunedin, New Zealand |
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| 基金项目： | Supported by the National Natural Science Foundation of China （20872033, 20575019）, Natural Science Foundation of Hunan Province （07JJ1003）, Key Laboratory of Chemical Biology and Traditional Chinese Medicine Research （Ministry of Education of China） （KLCBTCMR2008-14） and Scientific Research Fund of Science and Technology Department of Hunan Province （No. 2006GK3067） |
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| 摘 要： | The title compound ethyl 2-（6-（1,3-dioxo-4,5,6,7-tetrahydro-lH-isoindol-2（3H）- yl）-7-fluoro-3-oxo-2H-benzob]1,4]oxazin-4（3H）-yl） butanoate 3 was synthesized by the reaction of ethyl 2-（6-amino-7-fluoro-3-oxo-2H-benzob]1,4]oxazin-4（3H）-yl） butanoate with 4,5,6,7- tetraydrophthalic anhydride, and its structure was determined by X-ray single-crystal diffraction. The crystal belongs to the monoclinic system, space group P2 1/n with a = 9.3469（2）, b = 16.7715（5）, c = 13.7153（4） A, β= 104.9680（10）°, μ = 0.107 mm^-1, Mr = 430.42, V= 2077.08（10） ,A3, Z= 4, Dc = 1.376 g/cm3, F（000） = 904, T= 296（2） K, R = 0.0508 and wR = 0.1478.
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| 关 键 词： | 乙酸乙酯 晶体结构 氧代 合成 激素 四氢 小时 氟 |
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