Highly efficient synthesis of quinoxalinone-N-oxide via tandem nitrosation/aerobic oxidative C-N bond formation |
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| Authors: | Kobayashi Yusuke Kuroda Mami Toba Natsuki Okada Mari Tanaka Rie Kimachi Tetsutaro |
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| Affiliation: | Faculty of Pharmaceutical Sciences, Mukogawa Women's University, 11-68 Koshien Kyubancho, Nishinomiya 663-8179, Hyogo, Japan. ykoba@mukogawa-u.ac.jp |
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| Abstract: | An efficient method for constructing quinoxalinone-N-oxides from cyanoacetanilides has been developed. This transformation can be achieved using inexpensive reagents and molecular oxygen under mild conditions, thus offering a practical pathway to quinoxalinone-containing pharmaceuticals such as ataquimast and opaviraline. |
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