Tandem one-pot synthesis of polysubstituted pyridines using the Blaise reaction intermediate and 1,3-enynes |
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| Authors: | Chun Yu Sung Lee Jun Hee Kim Ju Hyun Ko Young Ok Lee Sang-gi |
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| Institution: | Department of Chemistry and Nano Science (BK21), Ewha Womans University, Seoul 120-750, Korea. |
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| Abstract: | A tandem one-pot method for the construction of a pyridine moiety with selective control of substitution patterns has been developed through the sequential reactions of nitrile with a Reformatsky reagent and 1,3-enyne involving regio- and chemoselective addition of the Blaise reaction intermediate to 1,3-enyne, followed by isomerization, cyclization, and an aromatization cascade. |
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