Catalyst-free preparation of 1,2,4,5-tetrasubstituted imidazoles from a novel unexpected domino reaction of 2-azido acrylates and nitrones |
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| Authors: | Hu Bao Wang Zhao Ai Ning Zheng Jie Liu Xing-Hai Shan Shang Wang Zhongwen |
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| Affiliation: | College of Chemical Engineering and Materials Science, Zhejiang University of Technology, Hangzhou 310014, PR China. hubao001@zjut.edu.cn |
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| Abstract: | A highly efficient and convenient method for the synthesis of 1,2,4,5-tetrasubstituted imidazoles from readily accessible 2-azido acrylates and nitrones has been developed. This reaction proceeded under mild conditions without the assistance of any metal, acid, or base. |
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