Enantioselective boronate additions to N-acyl quinoliniums catalyzed by tartaric acid |
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| Authors: | Kodama Tomohiro Moquist Philip N Schaus Scott E |
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| Affiliation: | Department of Chemistry and Center for Chemical Methodology and Library Development (CMLD-BU), Life Sciences and Engineering Building, Boston University, 24 Cummington Street, Boston, Massachusetts 02215, USA. |
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| Abstract: | Tartaric acid catalyzes the asymmetric addition of vinylboronates to N-acyl quinoliniums, affording highly enantioenriched dihydroquinolines. The catalyst serves to activate the boronate through a ligand-exchange reaction and generates the N-acyl quinolinium in situ from the stable quinoline-derived N,O-acetal. |
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