Intercepting Wacker intermediates with arenes: C-H functionalization and dearomatization |
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| Authors: | Matsuura Bryan S Condie Allison G McBee Ian A Buff Ryan C Karahalis Gregory J Stephenson Corey R J |
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| Affiliation: | Department of Chemistry, Boston University, Boston, Massachusetts 02215, USA. |
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| Abstract: | An intramolecular cyclization cascade reaction has been developed utilizing a high valent palladium intermediate that generates a carbon-carbon and carbon-oxygen bond in a single transformation. This method provides rapid access to highly functionalized tricyclic scaffolds, including spirocyclic cyclohexadienones. Good yields and mild conditions are reported with high tolerance toward oxygen and water. |
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