Remote Control of the Planar Chirality in Peptide‐Bound Metallomacrocycles and Dynamic‐to‐Static Planar Chirality Control Triggered by Solvent‐Induced 310‐to‐α‐Helix Transitions

The dynamic planar chirality in a peptide‐bound Ni^II‐salphen‐based macrocycle can be remotely controlled. First, a right‐handed (P)‐3₁₀‐helix is induced in the dynamic helical oligopeptides by a chiral amino acid residue far from the macrocyclic framework. The induced planar chirality remains dynamic in chloroform and acetonitrile, but is almost completely locked in fluoroalcohols as a result of the solvent‐induced transition of the peptide chains from a 3₁₀‐helix to a wider α‐helix, which freezes the rotation of the pendant peptide units around the macrocycle.