The thermoregulated ligand–palladium‐catalyzed carbonylative Sonogashira coupling of aryl iodides with terminal alkynes in water |
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Authors: | Yuanping Hao Jingyang Jiang Yanhua Wang Zilin Jin |
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Institution: | State Key Laboratory of Fine Chemicals, Faculty of Chemical, Environmental and Biological Science and Technology, Dalian University of Technology, Dalian, China |
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Abstract: | The carbonylative Sonogashira coupling of aryl iodides with terminal alkynes was studied by using thermoregulated ligand–palladium as an efficient and reusable catalyst at 80 °C in water. The corresponding alkynone products were obtained in good to excellent yields under 1 atm of carbon monoxide. The isolation of the products was readily achieved by extraction with ethyl acetate, and the catalyst recovered in water can be reused and recycled up to four times without significant loss in catalytic activity. Copyright © 2015 John Wiley & Sons, Ltd. |
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Keywords: | alkynones palladium carbonylative Sonogashira coupling thermoregulated phase‐transfer catalysis |
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