Palladium‐Catalyzed Heteroarylation and Concomitant ortho‐Alkylation of Aryl Iodides |
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Authors: | Chuanhu Lei Xiaojia Jin Jianrong Zhou |
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Institution: | Division of Chemistry and Biological Chemistry, School of Physical and Mathematical Sciences, Nanyang Technological University, 21 Nanyang Link, Singapore 637371 (Singapore) |
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Abstract: | Three‐component couplings were achieved from common aryl halides, alkyl halides, and heteroarenes under palladium and norbornene co‐catalysis. The reaction forges hindered aryl–heteroaryl bonds and introduces ortho‐alkyl groups to aryl rings. Various heterocycles such as oxazoles, thiazoles and thiophenes underwent efficient coupling. The heteroarenes were deprotonated in situ by bases without the assistance of palladium catalysts. |
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Keywords: | C H activation cross‐coupling heterocycles palladium synthetic method |
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