Alkene‐Directed N‐Attack Chemoselectivity in the Gold‐Catalyzed [2+2+1]‐Annulations of 1,6‐Enynes with N‐Hydroxyanilines |
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| Authors: | Dr Deepak B Huple Bhanudas D Mokar Prof Dr Rai‐Shung Liu |
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| Institution: | Department of Chemistry, National Tsing‐Hua University, Hsinchu, 30013 (Taiwan, ROC) |
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| Abstract: | Kinetically unstable nitrones are generated from gold‐catalyzed reactions of 1,6‐enynes with N‐hydroxyanilines, and subsequently trapped by tethered alkenes to furnish 2+2+1]‐annulations. Our experimental data reveal that such nitrones arise from atypical N‐attack chemoselectivity that is triggered by tethered alkenes to facilitate the key protodeauration reaction. |
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| Keywords: | annulations chemoselectivity gold catalyst N‐attack |
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