General Olefin Synthesis by the Palladium‐Catalyzed Heck Reaction of Amides: Sterically Controlled Chemoselective NC Activation |
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| Authors: | Guangrong Meng Prof?Dr Michal Szostak |
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| Institution: | Department of Chemistry, Rutgers University, 73 Warren Street, Newark, NJ 07102 (USA) |
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| Abstract: | Metal‐catalyzed reactions of amides proceeding via metal insertion into the N? CO bond are severely underdeveloped due to resonance stabilization of the amide bond. Herein we report the first Heck reaction of amides proceeding via highly chemoselective N? CO cleavage catalyzed by Pd0 utilizing amide bond ground‐state destabilization. Conceptually, this transformation provides access to a myriad of metal‐catalyzed transformations of amides via metal insertion/decarbonylation. |
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| Keywords: | amide bonds base‐free Heck reaction Heck reaction N C activation twisted amides |
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