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Novel organosilicon dendrons as effective linkers for biomolecules binding on a glass surface |
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| Authors: | Grzegorz Hreczycho Emilia Frydrych‐Tomczak Karolina Sterzynska Joanna Budna Agnieszka Malinska Hieronim Maciejewski Maciej Zabel |
| Affiliation: | 1. Faculty of Chemistry, Adam Mickiewicz University, Poznan, Poland;2. Wroclaw Research Center EIT+, BioMed, Wroclaw, Poland;3. Poznan Science and Technology Park, Adam Mickiewicz University Foundation, Poznan, Poland;4. Department of Histology and Embryology, Poznan University of Medical Sciences, Poznan, Poland |
| Abstract: | A new, flexible and selective protocol for the synthesis of new organofunctional silicon dendrons of the general formula EtOSi(CH2CH2SiMe2CH2CH2SiMe2R)3 (where R is an amine or epoxy substituent) has been developed. The title compounds have been efficiently obtained via Karstedt platinum‐catalysed hydrosilylation and linked to a glass surface. Modified solid supports are successfully applied in immobilization of proteins, especially monoclonal antibodies against a wide range of antigens. Copyright © 2015 John Wiley & Sons, Ltd. |
| Keywords: | dendrons hydrosilylation reactions glass surface epoxysilane aminosilane |