Desulfitative palladium‐catalyzed direct C‐3 arylation of indolizines with arylsulfonyl chlorides |
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| Authors: | Wei Zhang Fang Liu Baoli Zhao |
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| Affiliation: | 1. Department of Chemistry and Chemical Engineering, Xinxiang University, Xinxiang, Henan Province, China;2. Life Science Research Center, Hebei North University, Zhangjiakou, Hebei Province, China;3. Institute of Applied Chemistry and Department of Chemistry, Shaoxing University, Shaoxing, Zhejiang Province, China |
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| Abstract: | An efficient Pd‐catalyzed desulfitative approach to C‐3 arylation of indolizine derivatives has been developed, and the protocol uses readily available arylsulfonyl chlorides as the arylation reagent under nitrogen. This transformation was performed in a mixed solvent of 1‐methyl‐2‐pyrrolidone and dimethoxyethane using simple triphenylphosphine as a ligand, which provides a new method for the C‐3 arylation of indolizines. Copyright © 2015 John Wiley & Sons, Ltd. |
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| Keywords: | desulfitative arylation indolizines arylsulfonyl chlorides |
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