Gold Nanoparticles Supported on a Layered Double Hydroxide as Efficient Catalysts for the One‐Pot Synthesis of Flavones |
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| Authors: | Takafumi Yatabe Dr. Xiongjie Jin Dr. Kazuya Yamaguchi Prof. Dr. Noritaka Mizuno |
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| Affiliation: | Department of Applied Chemistry, School of Engineering, The University of Tokyo, 7‐3‐1 Hongo, Bunkyo‐ku, Tokyo 113‐8656 (Japan) |
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| Abstract: | Flavones are a class of natural products with diverse biological activities and have frequently been synthesized by step‐by‐step procedures using stoichiometric amounts of reagents. Herein, a catalytic one‐pot procedure for the synthesis of flavone and its derivatives is developed. In the presence of gold nanoparticles supported on a Mg‐Al layered double hydroxide (Au/LDH), various kinds of flavones can be synthesized starting from 2′‐hydroxyacetophenones and benzaldehydes (or benzyl alcohols). The present one‐pot procedure consists of a sequence of several reactions, and Au/LDH can catalyze all these different types of reactions. The catalysis is shown to be truly heterogeneous, and Au/LDH can be readily recovered and reused. |
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| Keywords: | flavones gold catalysis heterogeneous catalysis layered double hydroxides one‐pot synthesis |
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