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Use of p-nitrobenzyloxycarbonyl (pNZ) as a permanent protecting group in the synthesis of Kahalalide F analogs |
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| Authors: | Pilar E. Ló pez,Albert Isidro-Llobet,Luis J. Cruz,André s Parra,Fernando Albericio |
| Affiliation: | a Barcelona Biomedical Research Institute, Barcelona Science Park, Josep Samitier 1, 08028 Barcelona, Spain b Department of Organic Chemistry, University of Granada, 18071 Granada, Spain c Laboratory of Organic Chemistry, Faculty of Pharmacy, University of Barcelona, 08028 Barcelona, Spain d Department of Organic Chemistry, University of Barcelona, 08028 Barcelona, Spain |
| Abstract: | p-Nitrobenzyloxycarbonyl (pNZ) is used for the permanent protection of ornithine in the synthesis of derivatives of the anti-tumor cyclodepsipeptide Kahalalide F that contain acid labile residues. |
| Keywords: | Combinatorial chemistry Cyclic pepides Orthogonal protecting group |
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