New pyrrole-based amino acids for the synthesis of peptidomimetic constrained scaffolds |
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Authors: | Maddalena Alongi |
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Institution: | Dipartimento Farmaco Chimico Tecnologico, Università degli Studi di Siena, Via A. Moro, 53100 Siena, Italy |
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Abstract: | A new family of pyrrole-based amino acids have been prepared through the microwave assisted Paal-Knorr reaction of 1-4 ketoesters derived from the corresponding β-ketoester with a functional homologation. The carboxylic group is located in position 3 of the pyrrole, whereas the amino group, protected with the Cbz moiety, is present on the side chain in positions 1 or 2. These compounds were used to prepare constrained oligopeptides. |
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Keywords: | Paal-Knorr reaction Cyclocondensation Microwaves Peptides |
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