Palladium-catalyzed construction of amino acid derivatives possessing vicinal chiral quaternary and tertiary carbon centers at the α and β positions |
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| Authors: | Daiji Ikeda Junichi Uenishi |
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| Institution: | a Kyoto Pharmaceutical University, Misasagi, Yamashina, Kyoto 607-8412, Japan
b Faculty of Engineering, Tottori University, Koyama, Tottori 680-8552, Japan |
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| Abstract: | The palladium catalyzed regio- and diastereo-selective allylic alkylation of (R)-2-acetoxy-4-aryl-3-butene with N-(diphenylmethylidene)glycinate and N-(diphenylmethylidene)alaninate occurred. The stereochemistry was controlled by the use of o-(diphenylphosphino)carboxylic acid, and produced new amino acid derivatives possessing vicinal chiral quaternary and tertiary carbon centers at the α and β positions. |
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| Keywords: | Pd-catalyzed allylic alkylation Regio- and diastereo-selectivity Vicinal chiral carbon centers Amino acids derivatives |
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