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A concise synthesis of denbinobin |
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| Authors: | Yu-Chieh Wang Chi-Ming Chen |
| Affiliation: | a Department of Medicinal Chemistry, School of Pharmacy, Taipei Medical University, Taipei, Taiwan, ROC b Graduate Institute of Medical Sciences, Taipei Medical University, Taipei, Taiwan, ROC |
| Abstract: | A concise synthesis of denbinobin is described via an intramolecular free radical cyclization and Fremy’s salt mediated oxidation as a key reactions. A seven-step process starting from commercially available 3,5-dimethoxybenzyl bromide (6) and 2-bromoisovanillin (5) effectively constructs the natural product denbinobin (1). |
| Keywords: | Natural product Free radical cyclization Fremy&rsquo s salt oxidation |
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