Microwave-assisted solid-phase Dötz benzannulation reaction: a facile synthesis of 2,3-disubstituted-1,4-naphthoquinones |
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| Authors: | Muthian Shanmugasundaram |
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| Institution: | Department of Chemistry, University of Texas at El Paso, 500 West University Ave., El Paso, TX 79968, USA |
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| Abstract: | A microwave-assisted solid-supported Dötz benzannulation of chromium carbene complexes with various alkynes has been developed. The oxidative cleavage of the resulting resin-bound 1,4-naphthols affords 2,3-disubstituted-1,4-naphthoquinone derivatives in good to moderate yields with high purities. |
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| Keywords: | Solid-phase synthesis Microwave Dö tz reaction 1 4-Naphthoquinones Fischer carbenes |
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