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One-pot synthesis of α-amino phosphonates from α-amino acids and β-amino alcohols |
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| Authors: | Alicia Boto Carlos Javier Saavedra |
| Affiliation: | Instituto de Productos Naturales y Agrobiología del C.S.I.C., Avda. Astrofísico Fco. Sánchez 3, 38206-La Laguna, Tenerife, Spain |
| Abstract: | The one-pot radical fragmentation-phosphorylation reaction of α-amino acids and β-amino alcohols affords α-amino phosphonates in good yields. The reaction was applied to the synthesis of potentially bioactive phosphonates. |
| Keywords: | Amino acids Amino phosphonates Radicals Fragmentation Decarboxylation Hypervalent iodine reagents |
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