Synthetic studies of the HIV-1 protease inhibitive didemnaketals: precise and stereocontrolled synthesis of the key mother spiroketal |
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Authors: | Xue Zhi Zhao Shuan Hu Gao |
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Institution: | Department of Chemistry and State Key Laboratory of Applied Organic Chemistry, Lanzhou University, Lanzhou 730000, PR China |
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Abstract: | The precise and stereocontrolled synthesis of the C9-C23 portion, the key mother spiroketal of the HIV-1 protease inhibitive didemnaketals from the ascidian Didemnum sp., has been carried out through multisteps starting from (R)-pulegone as the chiral template. This approach involved the distereoselective construction of eight chiral centers by intramolecular chiral inducement and the coupling of two fragments by Julia reaction. |
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Keywords: | Key mother spiroketal HIV-1 protease Intramolecular chiral inducement Julia reaction |
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